Cytotoxic and Anti-Inflammatory Metabolites from the Soft Coral Scleronephthya gracillimum

نویسندگان

  • Hui-Yu Fang
  • Chi-Hsin Hsu
  • Chih-Hua Chao
  • Zhi-Hong Wen
  • Yang-Chang Wu
  • Chang-Feng Dai
  • Jyh-Horng Sheu
چکیده

Five new pregnane-type steroids, sclerosteroids J-N (1-5), and a diterpenoid with a new chemotype 3-methyl-5-(10'-acetoxy-2',6',10'-trimethylundecyl)-2-penten-5-olide (6), have been isolated from a soft coral Scleronephthya gracillimum. The structures of the metabolites were determined by extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against HepG2, A549, and MDA-MB-231 cancer cell lines. Furthermore, steroids 2 and 4 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein, and 1, 2, 4 and 5 could effectively reduce the accumulation of COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.

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عنوان ژورنال:

دوره 11  شماره 

صفحات  -

تاریخ انتشار 2013